We accelerated atherosclerotic development by feeding animal a high fat diet for three months. We hypothesized that increasing IGF1 levels strictly in macrophages will prevent atherosclerosis.Īfter breeding a novel macrophage-specific IGF1 overexpressing transgenic mouse to an Apoe -/- background (MF-IGF1 mice), we assessed atherosclerotic plaque burden, stability, and monocyte recruitment. Results of our previous in vitro experiments suggest that macrophages play a predominant role in mediating IGF1 effects in atherosclerotic plaque, but exact mechanisms remain unclear. IGF1 administration in ApoE deficient (Apoe -/-) mice fed a high fat diet reduced atherosclerosis and reduced plaque macrophages. Insulin Like Growth Factor I (IGF1) has been shown to reduce cardiovascular events. All information is believed to be accurate but is not guaranteed.1Tulane University School of Medicine, New Orleans, LAĢUniversity of Missouri System, Columbia, MOĪtherosclerosis is the leading cause of Cardiovascular Disease, which is still the global leader of mortality. The properties shown here may not be all properties available through the BR Program. Properties that are not listed by Emerald Coast Realty have the listing brokerage name clearly identified by the BR Program, including information provided by that brokerage. The MLS real estate data shown on this web site comes from the Broker Reciprocity (BR) Program with the Pensacola Association of Realtors.
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